|
|
tylactone + dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-glucopyranose <=> 5-O-beta-D-mycaminosyltylactone + dTDP + H+
|
2.4.1.316
tylactone mycaminosyltransferase
|
–
|
| |
BRENDA:
BR50949
KEGG:
R06450
MetaCyc:
RXN-15063
|
|
|
|
20-hydroxy-5-O-mycaminosyltylactone + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 20-oxo-5-O-beta-mycaminosyltylactone + oxidized_ferredoxin + H2O
|
1.14.15
|
–
|
| |
MetaCyc:
RXN-15061
|
|
|
|
S-adenosyl-L-methionine + Demethylmacrocin <=> H+ + S-adenosyl-L-homocysteine + macrocin
|
2.1.1.102
demethylmacrocin O-methyltransferase
|
–
|
| |
BRENDA:
BR43861
KEGG:
R02859
MetaCyc:
DEMETHYLMACROCIN-O-METHYLTRANSFERASE-RXN
|
|
|
|
20-oxo-5-O-beta-mycaminosyltylactone + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 5-O-beta-mycaminosyltylonolide + H2O + oxidized_ferredoxin
|
1.14.15.34
20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
|
–
|
| |
BRENDA:
BR50923
KEGG:
R10656
MetaCyc:
RXN-15060
|
|
|
|
S-adenosyl-L-methionine + macrocin <=> tylosin + S-adenosyl-L-homocysteine + H+
|
2.1.1.101
macrocin O-methyltransferase
|
–
|
| |
BRENDA:
BR43860
KEGG:
R02858
MetaCyc:
MACROCIN-O-METHYLTRANSFERASE-RXN
|
|
|
|
demethyllactenocin + dTDP-beta-L-mycarose <=> Demethylmacrocin + dTDP + H+
|
2.4.1.318
demethyllactenocin mycarosyltransferase
|
–
|
| |
BRENDA:
BR50951
KEGG:
R06452
MetaCyc:
RXN-15058
|
|
|
|
5-O-beta-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose <=> demethyllactenocin + dTDP + H+
|
2.4.1.317
O-mycaminosyltylonolide 6-deoxyallosyltransferase
|
–
|
| |
BRENDA:
BR50950
KEGG:
R06451
MetaCyc:
RXN-15059
|
|
|
|
malonyl-CoA + (S)-methylmalonyl-CoA + NADPH + H+ + (2S)-ethylmalonyl-CoA <=> tylactone + CoA + CO2 + H2O + NADP+
|
2.3.1
|
–
|
| |
KEGG:
R06448
MetaCyc:
RXN-15064
|
|
|
|
5-O-beta-D-mycaminosyltylactone + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 20-hydroxy-5-O-mycaminosyltylactone + H2O + oxidized_ferredoxin
|
1.14.15
|
–
|
| |
MetaCyc:
RXN-15062
|
|
